Trial Into Antioxidant for Parkinson’s Disease Yields Disappointing Results

Trial Into Antioxidant for Parkinson’s Disease Yields Disappointing Results

By Cara MurezHealthDay Reporter

FRIDAY, Sept. 17, 2021 (HealthDay News) – Researchers hoped to show that the natural antioxidant urate could delay Parkinson’s disease progression, but a study completed at Massachusetts General Hospital dashed those expectations.

The trial enrolled nearly 300 individuals recently diagnosed with early Parkinson’s disease, which affects the body’s motor system. Symptoms such as tremors, stiff limbs and balance problems progress gradually, and there is no known cure.

The research team found no significant difference in the rate of disease progression for those given the metabolite inosine for two years compared to the placebo group.

Inosine raises levels of urate in the brain and blood. It has appeared neuroprotective in preclinical models.

The inosine did not prove beneficial, and those who received it also had an increased rate of kidney stones, according to the study.

“The convergence of epidemiological, biological and clinical data from past research made a compelling argument that elevating urate, the main antioxidant circulating in the blood, could protect against the o

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